KeePassium supports Twofish in all database configurations (
It is compatible with Twofish databases edited by KeePassXC.
If you use Twofish plugin for KeePass2, please note that the plugin does not work well with the
kdbx4 format. In particular, after editing a database, it will not be able to read it. It is also unable to read
kdbx4 files saved either by KeePassium or KeePassXC.